Search results for "Posterior pituitary"

The oxytocin receptor system: structure, function, and regulation.

2001

The neurohypophysial peptide oxytocin (OT) and OT-like hormones facilitate reproduction in all vertebrates at several levels. The major site of OT gene expression is the magnocellular neurons of the hypothalamic paraventricular and supraoptic nuclei. In response to a variety of stimuli such as suckling, parturition, or certain kinds of stress, the processed OT peptide is released from the posterior pituitary into the systemic circulation. Such stimuli also lead to an intranuclear release of OT. Moreover, oxytocinergic neurons display widespread projections throughout the central nervous system. However, OT is also synthesized in peripheral tissues, e.g., uterus, placenta, amnion, corpus lut…

Oxytocin receptor ligands: a survey of the patent literature

2008

Background: Oxytocin is produced primarily in hypothalamic neurons and is secreted from the posterior pituitary gland into the circulation in response to stimuli such as suckling, parturition, or stress. Oxytocin functions as an essential component in milk ejection and is among the most potent uterotonic substances known. The oxytocin receptor system supports physiological processes associated with reproduction at several levels. Objective: To characterize and evaluate oxytocin receptor ligands for therapeutic applications. Methods: Analysis of oxytocin analogs and nonpeptide oxytocin receptor ligands, and major applications of these substances. Results/conclusion: Oxytocin receptor ligands…

Die Diurese der Maus nach oraler Gabe von Wasser oder NaCl-L�sungen und ihre Beeinflussung durch Hypophysenhinterlappenhormone

1959

MR IMAGING AND HORMONAL FINDINGS IN PATIENTS WITH IDIOPATHIC GROWTH HORMONU DEFICIENCY

1993

Until the introduction of MR imaging in neuroradiological diagnostic, diagnosis of the ecotopic posterior pituitary lobe, first described by the pathologist Priesel in 1920, was rare. Recently it has increasingly been diagnosed by MR in patients whose anamnesis showed birth trauma. We performed MR of the hypothalamic-pituitary region in 17 patients with idiopathic growth hormone deficiency. 8 patients had additional deficiencies of the anterior pituitary lobe whereas the function of the posterior lobe of the hypophysis was normal in all patients. Indications of birth trauma were present in only 2 patients. The cause of anterior lobe insufficiency was determined by MR in 8 patients with panh…